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Benzoyl Peroxide

"Enrolled patients were instructed to apply the assigned study gel in a quantity sufficient to cover the entire face once daily for 12 weeks." Kawashima, Makoto, et al. "Is benzoyl peroxide 3% topical gel effective and safe in the treatment of acne vulgaris in J apanese patients? A multicenter, randomized, double‐blind, vehicle‐controlled, parallel‐group study." The Journal of Dermatology 41.9 (2014): 795-801.

Adapalene

"Patients were instructed to apply treatment once daily in the evening for 12 weeks." Thiboutot, D., Pariser, D. M., Egan, N., Flores, J., Herndon, J. H., Jr, Kanof, N. B., Kempers, S. E., Maddin, S., Poulin, Y. P., Wilson, D. C., Hwa, J., Liu, Y., Graeber, M., & Adapalene Study Group (2006). Adapalene gel 0.3% for the treatment of acne vulgaris: a multicenter, randomized, double-blind, controlled, phase III trial. Journal of the American Academy of Dermatology, 54(2), 242–250. https://doi.org/10.1016/j.jaad.2004.10.879

Adapalene + BP

"Subjects were randomized consecutively in a 1:1:1:1 ratio to receive either adapalene–BPO gel, adapalene gel, BPO gel, or gel vehicle, once daily in the evening for 12 weeks." Gollnick, H. P., Draelos, Z., Glenn, M. J., Rosoph, L. A., Kaszuba, A., Cornelison, R., Gore, B., Liu, Y., Graeber, M., & Adapalene-BPO Study Group (2009). Adapalene-benzoyl peroxide, a unique fixed-dose combination topical gel for the treatment of acne vulgaris: a transatlantic, randomized, double-blind, controlled study in 1670 patients. The British journal of dermatology, 161(5), 1180–1189. https://doi.org/10.1111/j.1365-2133.2009.09209.x
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